日本機械学会北海道支部 特別講演会         2013.10.22


 

                            北海道支部 支部長  風間 俊治

 

この度、特別講演会が開催されます。皆様には是非ご参加くださいますようご案内とお願いを申し上げます。

                記


主催 : 日本機械学会北海道支部 バイオメカニクス懇話会
       主査 : 大橋 俊朗 (北海道大学大学院工学研究院 教授)

共催 : 日本機械学会バイオエンジニアリング部門「計測と力学−生体への応用−」研究会,
    日本機械学会北海道支部 
 

日時 : 20131029日(火) 1620〜17:00

場所 : 北海道大学大学院工学研究院・工学部(札幌市北区北13条西8丁目)A1-17大会議室    http://www.eng.hokudai.ac.jp/building/?place=outer

講師 :  Senior Lecturer Irza Sukmana, Ph.D. (Universiti Teknologi Malaysia, UTM Johor Bahru, Malaysia)

演題 :  「The Biomechanical Tuning of Fibrin Gel Toward Angiogenesis Guidance of Human Umbelical Vein Endothelial Cells

アブストラクト:The guidance of endothelial cell organization into a newly capillary-like network from the pre-existing ones (i.e.,angiogenesis) has been a long standing challenge in tissue engineering. Some research efforts have been made to develop methods to promote capillary-like structure inside engineered tissue constructs. Capillary and vascular networks that would mimic blood microvessel function can be used to subsequently facilitate oxygen and nutrient transfer as well as waste removal. Vascularization of engineering tissue construct is one of the most favorable strategies to overpass nutrient and oxygen supply limitation, which is often the major hurdle in developing thick and complex tissue and artificial organ. This work aims to determine the mechanical and biophysical properties of fibrin gel for the purpose of angiogenesis study and microvascular development in a three-dimensional (3D) environment. Recently, we have further investigated in vitro using Human Umbilical Vein Endothelial Cells (HUVECs) to find the tuning of biomechanical properties of fibrin gel for the guidance of HUVEC's angiogenesis in a three dimensional fibrin gel environment.

        Keywords: biomechanical properties, angiogenesis guidance, three-dimensional culturey, HUVECs.

連絡先・問い合わせ先 : 日本機械学会北海道支部事務局 jsme-hk@eng.hokudai.ac.jp または
 バイオメカニクス懇話会主査/北海道大学大学院工学研究院  大橋俊朗 教授  ohashi@eng.hokudai.ac.jp 011-706-6424